KEΦOYPOΞIMH AΞETIΛH

Eνδείξεις:

Oξεία βρογχίτιδα, παροξύνσεις χρόνιας βρογχίτιδας, οξεία μέση ωτίτιδα, οξεία παραρρινοκολπίτιδα, χρόνια παραρρινοκολπίτιδα (σε συνδυασμό με μια ιμιδαζόλη), ουρολοιμώξεις από εντεροβακτηριακά ανθεκτικά στην αμπικιλλίνη ή τις κεφαλοσπορίνες της α' γενεάς. Ήπιες λοιμώξεις μαλακών μορίων από ευαίσθητους μικροοργανισμούς. Γονόρροια

Microbiology: The in vivo bactericidal activity of cefuroxime axetil is due to cefuroxime's binding to essential target proteins and the resultant inhibition of cell-wall synthesis.
Cefuroxime has bactericidal activity against a wide range of common pathogens, including many beta-lactamase-producing strains. Cefuroxime is stable to many bacterial beta-lactamases, especially plasmid-mediated enzymes that are commonly found in enterobacteriaceae.
Cefuroxime has been demonstrated to be active against most strains of the following microorganisms both in vitro and in clinical infections as described in the

Aerobic Gram-Positive Microorganisms:
Staphylococcus aureus (including beta-lactamase-producing strains)
Streptococcus pneumoniae
Streptococcus pyogenes

Aerobic Gram-Negative Microorganisms:
Escherichia coli
Haemophilus influenzae (including beta-lactamase-producing strains)
Haemophilus parainfluenzae
Klebsiella pneumoniae
Moraxella catarrhalis (including beta-lactamase-producing strains)
Neisseria gonorrhoeae (including beta-lactamase-producing strains)
Spirochetes:
Borrelia burgdorferi

Cefuroxime has been shown to be active in vitro against most strains of the following microorganisms; however, the clinical significance of these findings is unknown.
Cefuroxime exhibits in vitro minimum inhibitory concentrations (MICs) of 4.0 mcg/mL or less (systemic susceptible breakpoint) against most (>/=90%) strains of the following microorganisms; however, the safety and effectiveness of cefuroxime in treating clinical infections due to these microorganisms have not been established in adequate and well-controlled trials.

Aerobic Gram-Positive Microorganisms:
Staphylococcus epidermidis
Staphylococcus saprophyticus
Streptococcus agalactiae
NOTE: Certain strains of enterococci, e.g., Enterococcus faecalis (formerly Streptococcus faecalis ), are resistant to cefuroxime. Methicillin-resistant staphylococci are resistant to cefuroxime.

Aerobic Gram-Negative Microorganisms:
Morganella morganii
Proteus inconstans
Proteus mirabilis
Providencia rettgeri

NOTE: Pseudomonas spp., Campylobacter spp., Acinetobacter calcoaceticus , and most strains of Serratia spp. and Proteus vulgaris are resistant to most first- and second-generation cephalosporins. Some strains of Morganella morganii, Enterobacter cloacae, and Citrobacter spp. have been shown by in vitro tests to be resistant to cefuroxime and other cephalosporins.

Anaerobic Microorganisms:
Peptococcus niger
NOTE: Most strains of Clostridium difficile and Bacteroides fragilis are resistant to cefuroxime.